| GILEAD SCIENCES INC |
GILD
|
49 477 157 |
8.7 |
590 490 |
| AMGEN INC |
AMGN
|
46 242 429 |
8.1 |
139 739 |
| VERTEX PHARMACEUTICALS INC |
VRTX
|
43 553 469 |
7.6 |
94 070 |
| REGENERON PHARMACEUTICALS INC |
REGN
|
41 186 508 |
7.2 |
39 376 |
| ASTRAZENECA ADR REPRESENTING .5 PL |
AZN
|
25 314 367 |
4.4 |
329 314 |
| ALNYLAM PHARMACEUTICALS INC |
ALNY
|
19 675 413 |
3.4 |
72 603 |
| BIOGEN INC |
BIIB
|
15 991 023 |
2.8 |
82 377 |
| MODERNA INC |
MRNA
|
13 899 852 |
2.4 |
217 389 |
| ILLUMINA INC |
ILMN
|
11 605 264 |
2.0 |
90 089 |
| SUMMIT THERAPEUTICS INC |
SMMT
|
9 834 120 |
1.7 |
409 755 |
| SANOFI ADR REPRESENTING SA |
SNY
|
9 526 948 |
1.7 |
165 341 |
| ARGENX SE ADR |
ARGX
|
9 446 638 |
1.7 |
18 175 |
| UNITED THERAPEUTICS CORP |
UTHR
|
9 010 092 |
1.6 |
25 177 |
| VIATRIS INC |
VTRS
|
7 738 665 |
1.4 |
675 866 |
| BIOMARIN PHARMACEUTICAL INC |
BMRN
|
7 483 412 |
1.3 |
107 706 |
| VAXCYTE INC |
PCVX
|
7 299 596 |
1.3 |
63 118 |
| INSMED INC |
INSM
|
7 058 691 |
1.2 |
97 187 |
| ROYALTY PHARMA PLC CLASS A |
RPRX
|
7 022 739 |
1.2 |
253 437 |
| INCYTE CORP |
INCY
|
6 938 331 |
1.2 |
108 922 |
| SAREPTA THERAPEUTICS INC |
SRPT
|
6 767 926 |
1.2 |
53 932 |
| NEUROCRINE BIOSCIENCES INC |
NBIX
|
6 653 326 |
1.2 |
57 115 |
| BIONTECH SE ADR |
BNTX
|
6 569 516 |
1.2 |
55 453 |
| MEDPACE HOLDINGS INC |
MEDP
|
6 261 720 |
1.1 |
17 598 |
| BEIGENE ADS REPRESENTING LTD |
BGNE
|
5 237 773 |
0.9 |
25 024 |
| ROIVANT SCIENCES LTD |
ROIV
|
4 884 058 |
0.9 |
417 798 |
| ASCENDIS PHARMA ADR REPRESENTING |
ASND
|
4 746 451 |
0.8 |
32 759 |
| INTRA CELLULAR THERAPIES INC |
ITCI
|
4 509 299 |
0.8 |
59 710 |
| EXELIXIS INC |
EXEL
|
4 239 594 |
0.7 |
161 324 |
| REVOLUTION MEDICINES INC |
RVMD
|
4 202 238 |
0.7 |
94 645 |
| HALOZYME THERAPEUTICS INC |
HALO
|
4 026 336 |
0.7 |
71 643 |
| JAZZ PHARMACEUTICALS PLC |
JAZZ
|
3 809 509 |
0.7 |
34 924 |
| CYTOKINETICS INC |
CYTK
|
3 504 049 |
0.6 |
66 541 |
| IONIS PHARMACEUTICALS INC |
IONS
|
3 409 724 |
0.6 |
83 164 |
| NUVALENT INC CLASS A |
NUVL
|
3 386 965 |
0.6 |
33 435 |
| BLUEPRINT MEDICINES CORP |
BPMC
|
3 233 922 |
0.6 |
35 825 |
| ULTRAGENYX PHARMACEUTICAL INC |
RARE
|
2 996 145 |
0.5 |
52 125 |
| KRYSTAL BIOTECH INC |
KRYS
|
2 924 643 |
0.5 |
16 296 |
| AVIDITY BIOSCIENCES INC |
RNA
|
2 914 516 |
0.5 |
66 239 |
| MADRIGAL PHARMACEUTICALS INC |
MDGL
|
2 739 076 |
0.5 |
12 279 |
| BRIDGEBIO PHARMA INC |
BBIO
|
2 630 958 |
0.5 |
105 831 |
| ADMA BIOLOGICS INC |
ADMA
|
2 559 590 |
0.4 |
132 690 |
| ARCELLX INC |
ACLX
|
2 555 003 |
0.4 |
30 260 |
| ALKERMES |
ALKS
|
2 548 940 |
0.4 |
93 129 |
| AXSOME THERAPEUTICS INC |
AXSM
|
2 482 079 |
0.4 |
27 183 |
| DENALI THERAPEUTICS INC |
DNLI
|
2 445 338 |
0.4 |
80 651 |
| IMMUNOVANT INC |
IMVT
|
2 378 995 |
0.4 |
82 604 |
| CRISPR THERAPEUTICS AG |
CRSP
|
2 274 368 |
0.4 |
48 608 |
| CRINETICS PHARMACEUTICALS INC |
CRNX
|
2 255 052 |
0.4 |
45 264 |
| APELLIS PHARMACEUTICALS INC |
APLS
|
2 110 680 |
0.4 |
68 640 |
| LEGEND BIOTECH ADR REP CORP |
LEGN
|
2 090 966 |
0.4 |
46 199 |
| KYMERA THERAPEUTICS INC |
KYMR
|
1 914 014 |
0.3 |
36 527 |
| DYNE THERAPEUTICS INC |
DYN
|
1 896 518 |
0.3 |
56 782 |
| AMICUS THERAPEUTICS INC |
FOLD
|
1 879 484 |
0.3 |
167 512 |
| MERUS NV |
MRUS
|
1 838 622 |
0.3 |
38 586 |
| RHYTHM PHARMACEUTICALS INC |
RYTM
|
1 766 806 |
0.3 |
34 481 |
| XENON PHARMACEUTICALS INC |
XENE
|
1 661 532 |
0.3 |
42 680 |
| IOVANCE BIOTHERAPEUTICS INC |
IOVA
|
1 603 295 |
0.3 |
171 659 |
| PTC THERAPEUTICS INC |
PTCT
|
1 584 091 |
0.3 |
43 376 |
| GERON CORP |
GERN
|
1 572 809 |
0.3 |
341 915 |
| GUARDANT HEALTH INC |
GH
|
1 561 377 |
0.3 |
69 210 |
| PROTAGONIST THERAPEUTICS INC |
PTGX
|
1 544 872 |
0.3 |
33 166 |
| TWIST BIOSCIENCE CORP |
TWST
|
1 529 927 |
0.3 |
32 930 |
| APOGEE THERAPEUTICS INC |
APGE
|
1 523 885 |
0.3 |
25 432 |
| IDEAYA BIOSCIENCES INC |
IDYA
|
1 498 858 |
0.3 |
47 780 |
| AGIOS PHARMACEUTICALS INC |
AGIO
|
1 495 958 |
0.3 |
32 109 |
| STRUCTURE THERAPEUTICS ADR INC |
GPCR
|
1 483 385 |
0.3 |
33 698 |
| ACADIA PHARMACEUTICALS INC |
ACAD
|
1 480 010 |
0.3 |
93 435 |
| VERACYTE INC |
VCYT
|
1 458 316 |
0.3 |
43 235 |
| VERA THERAPEUTICS INC CLASS A |
VERA
|
1 445 020 |
0.3 |
30 936 |
| JANUX THERAPEUTICS INC |
JANX
|
1 424 559 |
0.2 |
29 324 |
| ARROWHEAD PHARMACEUTICALS INC |
ARWR
|
1 414 673 |
0.2 |
70 242 |
| IMMUNITYBIO INC |
IBRX
|
1 408 021 |
0.2 |
391 117 |
| EDGEWISE THERAPEUTICS INC |
EWTX
|
1 377 648 |
0.2 |
53 150 |
| MYRIAD GENETICS INC |
MYGN
|
1 359 014 |
0.2 |
51 187 |
| SPRINGWORKS THERAPEUTICS INC |
SWTX
|
1 347 020 |
0.2 |
41 898 |
| AMPHASTAR PHARMACEUTICALS INC |
AMPH
|
1 310 617 |
0.2 |
27 656 |
| VERICEL CORP |
VCEL
|
1 258 267 |
0.2 |
28 124 |
| INTELLIA THERAPEUTICS INC |
NTLA
|
1 233 494 |
0.2 |
57 452 |
| HARMONY BIOSCIENCES HLDG INC |
HRMY
|
1 217 879 |
0.2 |
32 202 |
| VERONA PHARMA ADR PLC |
VRNA
|
1 210 572 |
0.2 |
40 815 |
| NOVAVAX INC |
NVAX
|
1 203 382 |
0.2 |
90 548 |
| KEROS THERAPEUTICS INC |
KROS
|
1 179 675 |
0.2 |
21 221 |
| BEAM THERAPEUTICS INC |
BEAM
|
1 153 018 |
0.2 |
46 549 |
| FORTREA HOLDINGS INC |
FTRE
|
1 093 842 |
0.2 |
49 250 |
| AKERO THERAPEUTICS INC |
AKRO
|
1 096 867 |
0.2 |
39 104 |
| RECURSION PHARMACEUTICALS INC CLAS |
RXRX
|
1 064 167 |
0.2 |
155 580 |
| MIRUM PHARMACEUTICALS INC |
MIRM
|
1 046 924 |
0.2 |
26 858 |
| LIGAND PHARMACEUTICALS INC |
LGND
|
1 039 197 |
0.2 |
10 440 |
| USD CASH |
|
1 006 300 |
0.2 |
1 006 300 |
| MANNKIND CORP |
MNKD
|
999 323 |
0.2 |
153 979 |
| NOVOCURE LTD |
NVCR
|
999 896 |
0.2 |
60 858 |
| ARVINAS INC |
ARVN
|
956 976 |
0.2 |
38 697 |
| SUPERNUS PHARMACEUTICALS INC |
SUPN
|
960 050 |
0.2 |
31 405 |
| ROCKET PHARMACEUTICALS INC |
RCKT
|
938 972 |
0.2 |
51 338 |
| HARROW INC |
HROW
|
918 613 |
0.2 |
20 009 |
| NURIX THERAPEUTICS INC |
NRIX
|
884 568 |
0.2 |
36 432 |
| BIOCRYST PHARMACEUTICALS INC |
BCRX
|
879 876 |
0.2 |
115 318 |
| SYNDAX PHARMACEUTICALS INC |
SNDX
|
878 555 |
0.2 |
48 061 |
| KURA ONCOLOGY INC |
KURA
|
853 845 |
0.2 |
43 080 |
| DYNAVAX TECHNOLOGIES CORP |
DVAX
|
813 423 |
0.1 |
74 832 |
| DAY ONE BIOPHARMACEUTICALS INC |
DAWN
|
809 808 |
0.1 |
56 472 |
| DISC MEDICINE INC |
IRON
|
793 237 |
0.1 |
16 813 |
| ARDELYX INC |
ARDX
|
784 622 |
0.1 |
132 314 |
| OCULAR THERAPEUTIX INC |
OCUL
|
752 363 |
0.1 |
87 586 |
| ARS PHARMACEUTICALS INC |
SPRY
|
742 810 |
0.1 |
54 299 |
| XENCOR INC |
XNCR
|
711 351 |
0.1 |
35 198 |
| TARSUS PHARMACEUTICALS INC |
TARS
|
705 520 |
0.1 |
21 360 |
| COLLEGIUM PHARMACEUTICAL INC |
COLL
|
699 115 |
0.1 |
18 500 |
| ANI PHARMACEUTICALS INC |
ANIP
|
698 143 |
0.1 |
11 930 |
| AVADEL PHARMACEUTICALS ORD |
AVDL
|
694 682 |
0.1 |
54 357 |
| MARAVAI LIFESCIENCES HOLDINGS INC |
MRVI
|
676 574 |
0.1 |
80 068 |
| INNOVIVA INC |
INVA
|
678 358 |
0.1 |
35 892 |
| COGENT BIOSCIENCES INC |
COGT
|
677 284 |
0.1 |
61 909 |
| PHATHOM PHARMACEUTICALS INC |
PHAT
|
665 139 |
0.1 |
38 626 |
| PROTHENA PLC |
PRTA
|
665 092 |
0.1 |
30 204 |
| IMMUNOCORE HOLDINGS ADR PLC |
IMCR
|
660 117 |
0.1 |
21 960 |
| TRAVERE THERAPEUTICS INC |
TVTX
|
647 483 |
0.1 |
44 470 |
| ENLIVEN THERAPEUTICS INC |
ELVN
|
640 189 |
0.1 |
26 597 |
| ARCUTIS BIOTHERAPEUTICS INC |
ARQT
|
633 652 |
0.1 |
65 460 |
| ZAI LABORATORY ADR REPRESENTING LT |
ZLAB
|
627 687 |
0.1 |
29 100 |
| CENTESSA PHARMACEUTICALS AMERICAN |
CNTA
|
620 443 |
0.1 |
39 977 |
| GRIFOLS ADR REPRESENTING ONE NON-V |
GRFS
|
602 796 |
0.1 |
69 287 |
| ANAPTYSBIO INC |
ANAB
|
595 785 |
0.1 |
17 081 |
| VIR BIOTECHNOLOGY INC |
VIR
|
585 171 |
0.1 |
77 609 |
| CULLINAN THERAPEUTICS INC |
CGEM
|
575 195 |
0.1 |
32 589 |
| AURINIA PHARMACEUTICALS INC |
AUPH
|
576 089 |
0.1 |
82 064 |
| WAVE LIFE SCIENCES LTD |
WVE
|
569 041 |
0.1 |
69 480 |
| GENMAB SPONSORED ADR |
GMAB
|
563 082 |
0.1 |
23 452 |
| EVOLUS INC |
EOLS
|
558 305 |
0.1 |
35 403 |
| KINIKSA PHARMACEUTICALS INTERNATIO |
KNSA
|
560 711 |
0.1 |
22 933 |
| RELAY THERAPEUTICS INC |
RLAY
|
550 008 |
0.1 |
75 447 |
| SANA BIOTECHNOLOGY INC |
SANA
|
515 593 |
0.1 |
126 062 |
| ZYMEWORKS INC |
ZYME
|
508 825 |
0.1 |
40 706 |
| PETIQ INC CLASS A |
PETQ
|
499 173 |
0.1 |
16 228 |
| BICYCLE THERAPEUTICS ADR PLC |
BCYC
|
494 656 |
0.1 |
20 960 |
| E-MINI HEALTH CARE SECTOR DEC 24 |
IXCZ4
|
471 840 |
0.1 |
3 |
| CASTLE BIOSCIENCES INC |
CSTL
|
462 676 |
0.1 |
15 818 |
| 89BIO INC |
ETNB
|
453 526 |
0.1 |
59 911 |
| TANGO THERAPEUTICS INC |
TNGX
|
450 136 |
0.1 |
60 421 |
| RUSSELL 2000 EMINI CME DEC 24 |
RTYZ4
|
449 300 |
0.1 |
4 |
| ABCELLERA BIOLOGICS INC |
ABCL
|
425 867 |
0.1 |
168 995 |
| ARBUTUS BIOPHARMA CORP |
ABUS
|
428 917 |
0.1 |
106 696 |
| REPLIMUNE GROUP INC |
REPL
|
427 833 |
0.1 |
38 648 |
| ORIC PHARMACEUTICALS INC |
ORIC
|
420 529 |
0.1 |
39 119 |
| CUREVAC NV |
CVAC
|
409 739 |
0.1 |
128 445 |
| HUMACYTE INC |
HUMA
|
412 114 |
0.1 |
67 339 |
| SAVARA INC |
SVRA
|
411 568 |
0.1 |
93 115 |
| ERASCA INC |
ERAS
|
405 118 |
0.1 |
159 810 |
| OLEMA PHARMACEUTICALS INC |
OLMA
|
399 195 |
0.1 |
31 632 |
| AUTOLUS THERAPEUTICS ADR PLC |
AUTL
|
395 857 |
0.1 |
112 780 |
| SCHOLAR ROCK HOLDING CORP |
SRRK
|
389 629 |
0.1 |
45 096 |
| PLIANT THERAPEUTICS INC |
PLRX
|
384 483 |
0.1 |
33 935 |
| TERNS PHARMACEUTICALS INC |
TERN
|
384 073 |
0.1 |
39 966 |
| PACIRA BIOSCIENCES INC |
PCRX
|
368 007 |
0.1 |
25 807 |
| ADAPTIVE BIOTECHNOLOGIES CORP |
ADPT
|
363 565 |
0.1 |
87 186 |
| IRONWOOD PHARMA INC CLASS A |
IRWD
|
361 317 |
0.1 |
89 880 |
| TOURMALINE BIO INC |
TRML
|
360 644 |
0.1 |
15 314 |
| 4D MOLECULAR THERAPEUTICS INC |
FDMT
|
335 898 |
0.1 |
29 234 |
| SIGA TECHNOLOGIES INC |
SIGA
|
334 025 |
0.1 |
41 701 |
| ARCTURUS THERAPEUTICS HOLDINGS INC |
ARCT
|
332 795 |
0.1 |
15 308 |
| GALAPAGOS ADR REPRESENTING NV |
GLPG
|
331 659 |
0.1 |
11 496 |
| MINERALYS THERAPEUTICS INC |
MLYS
|
328 454 |
0.1 |
28 073 |
| THIRD HARMONIC BIO INC |
THRD
|
333 605 |
0.1 |
23 846 |
| Y MABS THERAPEUTICS INC |
YMAB
|
332 089 |
0.1 |
25 644 |
| REVANCE THERAPEUTICS INC |
RVNC
|
324 529 |
0.1 |
59 059 |
| LEXICON PHARMACEUTICALS INC |
LXRX
|
320 886 |
0.1 |
204 386 |
| UROGEN PHARMA LTD |
URGN
|
311 128 |
0.1 |
23 823 |
| REGENXBIO INC |
RGNX
|
312 232 |
0.1 |
27 853 |
| ALLOGENE THERAPEUTICS INC |
ALLO
|
315 198 |
0.1 |
118 052 |
| HUTCHMED CHINA ADR LTD |
HCM
|
301 629 |
0.1 |
17 385 |
| ALECTOR INC |
ALEC
|
298 573 |
0.1 |
57 418 |
| ACELYRIN INC |
SLRN
|
287 475 |
0.0 |
58 549 |
| OMNIAB INC |
OABI
|
282 918 |
0.0 |
66 569 |
| ANAVEX LIFE SCIENCES CORP |
AVXL
|
273 223 |
0.0 |
49 141 |
| PACIFIC BIOSCIENCES OF CALIFORNIA |
PACB
|
262 447 |
0.0 |
151 704 |
| EYEPOINT PHARMACEUTICALS INC |
EYPT
|
254 086 |
0.0 |
30 466 |
| TAYSHA GENE THERAPIES INC |
TSHA
|
251 540 |
0.0 |
122 107 |
| SAGE THERAPEUTICS INC |
SAGE
|
244 906 |
0.0 |
33 503 |
| KALVISTA PHARMACEUTICALS INC |
KALV
|
240 092 |
0.0 |
24 880 |
| PHIBRO ANIMAL HEALTH CORP CLASS A |
PAHC
|
237 370 |
0.0 |
10 770 |
| PRIME MEDICINE INC |
PRME
|
237 594 |
0.0 |
67 884 |
| GRAIL INC |
GRAL
|
232 534 |
0.0 |
17 563 |
| VERVE THERAPEUTICS INC |
VERV
|
226 081 |
0.0 |
45 673 |
| XERIS BIOPHARMA HOLDINGS INC |
XERS
|
230 154 |
0.0 |
81 615 |
| NAUTILUS BIOTECHNOLGY INC |
NAUT
|
229 870 |
0.0 |
76 116 |
| MAXCYTE INC |
MXCT
|
225 540 |
0.0 |
57 831 |
| ITEOS THERAPEUTICS INC |
ITOS
|
223 204 |
0.0 |
22 034 |
| LYELL IMMUNOPHARMA INC |
LYEL
|
216 007 |
0.0 |
147 950 |
| THERAVANCE BIOPHARMA INC |
TBPH
|
214 262 |
0.0 |
26 716 |
| AC IMMUNE SA |
ACIU
|
200 880 |
0.0 |
54 000 |
| VOYAGER THERAPEUTICS INC |
VYGR
|
194 614 |
0.0 |
32 221 |
| MEIRAGTX HOLDINGS PLC |
MGTX
|
176 449 |
0.0 |
43 784 |
| VANDA PHARMACEUTICALS INC |
VNDA
|
173 347 |
0.0 |
34 949 |
| BIOMEA FUSION INC |
BMEA
|
163 072 |
0.0 |
20 384 |
| ATEA PHARMACEUTICALS INC |
AVIR
|
158 606 |
0.0 |
45 316 |
| ZENTALIS PHARMACEUTICALS INC |
ZNTL
|
152 796 |
0.0 |
38 009 |
| EDITAS MEDICINE INC |
EDIT
|
156 548 |
0.0 |
44 348 |
| EXSCIENTIA ADR PLC |
EXAI
|
148 976 |
0.0 |
29 154 |
| PRECIGEN INC |
PGEN
|
145 626 |
0.0 |
150 581 |
| AMARIN ADR REPRESENTING PLC |
AMRN
|
138 431 |
0.0 |
237 366 |
| ATAI LIFE SCIENCES N V NV |
ATAI
|
123 425 |
0.0 |
104 598 |
| UNIQURE NV |
QURE
|
126 952 |
0.0 |
24 699 |
| FULCRUM THERAPEUTICS INC |
FULC
|
116 545 |
0.0 |
36 307 |
| AMYLYX PHARMACEUTICALS INC |
AMLX
|
109 666 |
0.0 |
36 434 |
| CABALETTA BIO INC |
CABA
|
109 729 |
0.0 |
27 296 |
| MACROGENICS INC |
MGNX
|
99 978 |
0.0 |
33 326 |
| VENTYX BIOSCIENCES INC |
VTYX
|
101 634 |
0.0 |
41 315 |
| CARIBOU BIOSCIENCES INC |
CRBU
|
94 631 |
0.0 |
49 287 |
| 23ANDME HOLDING CLASS A |
ME
|
69 262 |
0.0 |
203 714 |
| COHERUS BIOSCIENCES INC |
CHRS
|
60 512 |
0.0 |
60 512 |
| ALX ONCOLOGY HOLDINGS INC |
ALXO
|
59 689 |
0.0 |
30 610 |
| CASH COLLATERAL USD HSBFT |
HSBFT
|
56 000 |
0.0 |
56 000 |
| MARINUS PHARMACEUTICALS INC |
MRNS
|
55 700 |
0.0 |
29 316 |
| BLUEBIRD BIO INC |
BLUE
|
50 971 |
0.0 |
101 942 |
| ACLARIS THERAPEUTICS INC |
ACRS
|
44 140 |
0.0 |
38 052 |
| OVID THERAPEUTICS INC |
OVID
|
43 285 |
0.0 |
37 970 |
| GBP CASH |
|
36 986 |
0.0 |
27 629 |
| RAPT THERAPEUTICS INC |
RAPT
|
32 531 |
0.0 |
18 484 |
| RENEO PHARMACEUTICALS INC |
RPHM
|
32 527 |
0.0 |
23 069 |
| EUR CASH |
|
4 287 |
0.0 |
3 845 |
| OMNIAB INC $12.50 VESTING Prvt |
|
0 |
0.0 |
2 830 |
| OMNIAB INC $15.00 VESTING Prvt |
|
0 |
0.0 |
2 830 |
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